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Upon initiation or discontinuation of guselkumab in patients who will be acquiring concomitant CYP450 substrates, specially those with a slim therapeutic index, consider monitoring for therapeutic effect.フェニトインやカルバマゼピン、バルプロ酸など他の抗てんかん薬と同様に葉酸の吸収や代謝に影響し、貧